Fetal Nutrition, Metabolism, and Immunology: The Role of the Placenta (Trophoblast Research)

Each year since 1961, the Rochester Trophoblast Conference has grown in the diversity of its approaches to trophoblast research. At the Ninth Conference, Professors Klopper, Villee and Winick molded the conference with their state of the art addresses on Endocrinology, Metabolism and Nutrition of the Trophoblast. The Conference was favored with a multitude of creative studies and with warm, sunny, autumn weather to discuss these results. In October of 1982, one hundred and five investigators from 12 countries and 21 states discussed 42 different presentations at the Holiday Inn in Rochester, New York. The Ninth Conference introduced workshops on Metabolism, Nutrition, Endocrinology and Trophoblastic Neoplasia. The chairmen of these workshops were: Metabolism -Villee and Miller; Nutrition - Winick and Maulik; Endocrinology - Klopper and Muechler; and Trophoblastic Neoplasia -Szulman and Helmkamp. These two-hour, intimate discussion groups were well-received by all who attended. As with the Eighth Conference, the University of Rochester will no longer produce a transcript of the Conference. Beginning with the Ninth Conference, Plenum Press in association with the University, will publish a peer-reviewed series entitled Trophoblast Research. An international editorial advisory board has been named to assure the direction of the series. The editorial board and the organizing committee will develop the future meetings of the Rochester Trophoblast Conference. Trophoblast Research will be published as single bound volumes with original contributions and editorial reports of presentations from the Conference. History of the Rochester Trophoblast Conferences.- Nutrition.- Nutrition, Intrauterine Growth Retardation and the Placenta.- The Ultrastructural Basis of the Nutritional Transfer: Evidence of Different Patterns in the Plasma Membranes of the Multilayered Placental Barrier.- Human Placental Amino Acid Transfer and Metabolism in Oxygenated and Anoxic Conditions.- Bidirectional Transfer of ?-Aminoisobutyric Acid by the Perfused Human Placental Lobule.- The Effects of Anoxia on Human Placental Metabolism and Fetal Substrate Profile Investigated by an In Vitro Placental Perfusion Technique.- Clearance of ?-Aminoisobutyric Acid during In Situ Perfusion of the Guinea Pig Placenta.- Factors Affecting the Uptake of ?-Amino Acids by Human Placental Villus: Acetylcholine, Phospholipid Methylation, Ca++ and Cytoskeletal Organization.- Depression of Amino Acid Uptake in Human Placental Villus by Cocaine, Morphine and Nicotine.- Transport of Nutrients in the Early Human Placenta: Amino Acid, Creatine, Vitamin B12.- Studies on the Placental Hydrolysis and Transfer of Lipids to the Fetal Guinea Pig.- Doppler Assessment of Fetoplacental Circulatory Dynamics.- Fine Structure of the Human Chorion Laeve.- Nutrition Reports.- Metabolism.- Enzymes, Receptors, Metabolism and Placental Function.- cAMP-Dependent Protein Kinase and cAMP, cGMP and Calcium Stimulated Phosphorylation in Human Placenta: Comparison of Cytosol and Membrane Fractions.- Interaction between Membrane Function and Protein Synthesis in the Human Placenta In Vitro.- Metabolic Changes in Human Placental Tissue in Diabetes Mellitus.- Steroid and Protein Metabolism by the Trophoblast.- In Vivo and In Vitro Studies of the Dehydroepiandosterone Sulfate Metabolism in Cases of Impaired Estrogen Secretion.- The Placenta as a Target Tissue for Steroids.- The Placental Secretion of SP1: A Comparison of Concentrations in Retroplacental and Peripheral Blood.- Storage and Release of Renin and hCG in Trophoblast from Human Chorion Laeve.- The Arachidonic Acid Pathway and the Secretion of Chorionic Gonadotropin (hCG) and Progesterone by the Cultured Human Choriocarcinoma JEG-3 Cell.- Metabolism Reports.- Immunology.- Antibody-Induced Abortion in pp Women in Three Different Studies.- A Cell-Mediated Immune Defect in Recurrent Spontaneous Abortions.- Pregnancy-Associated Plasma Protein-A (PAPP-A) is a Specific Inhibitor of the Third Component of Human Complement.- The Embryopathologic Effects of Teratogenic Yolk Sac Antiserum.- Analysis of Sera from Monkeys with Histories of Fetal Wastage and the Identification of Teratogenicity in Sera from Human Chronic Spontaneous Aborters using Rat Embryo Cultures.- Prolonged Survival of Human Decidual Grafts in a Xenogeneic Host.- Immunology Reports.- List of Contributors.